Expressive

rs12299509 - CCND2

Magnitude 2.2 · 2 studies on file

Reported associations

  • Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes - Unknown journal (n.d.) · Unknown authors · PubMed 30054458

    ABSTRACT: Type 2 diabetes (T2D) is a very common disease in humans. Here we conduct a meta-analysis of genome-wide association studies (GWAS) with ~16 million genetic variants in 62,892 T2D cases and 596,424 controls of European ancestry. We identify 139 common and 4 rare variants associated with T2D, 42 of which (39 common and 3 rare variants) are independent of the known variants. Integration of the gene expression data from blood (n = 14,115 and 2765) with the GWAS results identifies 33 putative functional genes for T2D, 3 of which were targeted by approved drugs. A further integration of DNA methylation (n = 1980) and epigenomic annotation data highlight 3 genes (CAMK1D, TP53INP1, and ATP5G1) with plausible regulatory mechanisms, whereby a genetic variant exerts an effect on T2

  • A saturated map of common genetic variants associated with human height - Unknown journal (n.d.) · Unknown authors · PubMed 36224396

    ABSTRACT: Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes. Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Healthy weight maintenance for diabetes prevention Moderate

    Weight management reduces insulin resistance and metabolic stress, mitigating T2D genetic risk

    Maintain BMI 18.5-24.9 through balanced diet and calorie management

Exercise

  • Regular aerobic exercise for diabetes prevention Moderate

    Physical activity improves insulin sensitivity and glucose tolerance, offsetting genetic risk

    150 minutes moderate-intensity aerobic activity weekly

Screening

  • Type 2 diabetes risk screening Moderate

    G allele at rs12299509 increases genetic risk for type 2 diabetes requiring baseline and periodic monitoring

    HbA1c and fasting glucose baseline testing, then annually