rs1229762 - FOXP2
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates - Unknown journal (n.d.) · Unknown authors · PubMed 30846698
ABSTRACT: Sleep is an essential state of decreased activity and alertness but molecular factors regulating sleep duration remain unknown. Through genome-wide association analysis in 446,118 adults of European ancestry from the UK Biobank, we identify 78 loci for self-reported habitual sleep duration (p < 5 × 10−8; 43 loci at p < 6 × 10−9). Replication is observed for PAX8, VRK2, and FBXL12/UBL5/PIN1 loci in the CHARGE study (n = 47,180; p < 6.3 × 10−4), and 55 signals show sign-concordant effects. The 78 loci further associate with accelerometer-derived sleep duration, daytime inactivity, sleep efficiency and number of sleep bouts in secondary analysis (n = 85,499). Loci are enriched for pathways including striatum and subpallium development, mechan
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic sleep duration predisposition and daytime function Moderate
Genetic predisposition to short sleep warrants clinical assessment for underlying sleep disorders or adjustment needs
Lifestyle
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sleep duration and quality High
rs1229762 T allele associated with shorter habitual sleep duration in genome-wide association study of 411,934 individuals
track sleep duration over 2-4 weeks to establish baseline; note sleep-wake times and daytime sleepiness patterns