rs12296937 - ACSS3, ACSS3-AS1

Magnitude 2.2 · 1 study on file

Reported associations

• Electronic medical records and genomics (eMERGE) network exploration in cataract: Several new potential susceptibility loci - Unknown journal (n.d.) · Unknown authors · PubMed 25352737

  ABSTRACT: Purpose Cataract is the leading cause of blindness in the world, and in the United States accounts for approximately 60% of Medicare costs related to vision. The purpose of this study was to identify genetic markers for age-related cataract through a genome-wide association study (GWAS). Methods In the electronic medical records and genomics (eMERGE) network, we ran an electronic phenotyping algorithm on individuals in each of five sites with electronic medical records linked to DNA biobanks. We performed a GWAS using 530,101 SNPs from the Illumina 660W-Quad in a total of 7,397 individuals (5,503 cases and 1,894 controls). We also performed an age-at-diagnosis case-only analysis. Results We identified several statistically significant associations with age-related cataract (45 SN

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