rs12295992 - SLC3A2 - CHRM1

Magnitude 2.0 · 1 study on file

Reported associations

• A comprehensive analysis of SNPs and CNVs identifies novel markers associated with disease outcomes in colorectal cancer - Unknown journal (n.d.) · Unknown authors · PubMed 34309201

  ABSTRACT: We aimed to examine the associations of a genome‐wide set of single nucleotide polymorphisms (SNPs) and 254 copy number variations (CNVs) and/or insertion/deletions (INDELs) with clinical outcomes in colorectal cancer patients (n = 505). We also aimed to investigate whether their associations changed (e.g., appeared, diminished) over time. Multivariable Cox proportional hazards and piece‐wise Cox regression models were used to examine the associations. The Cancer Genome Atlas (TCGA) datasets were used for replication purposes and to examine the gene expression differences between tumor and nontumor tissue samples. A common SNP (WBP11‐rs7314075) was associated with disease‐specific survival with P‐value of 3.2 × 10−8. Association of this region with disease‐

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