rs12291066 - MICAL2
Magnitude 2.8 · 1 study on file
Reported associations
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Meta-analysis of genome-wide association studies identifies genetic risk factors for stroke in African-Americans - Unknown journal (n.d.) · Unknown authors · PubMed 26089329
ABSTRACT: Background and Purpose The majority of genome-wide association studies (GWAS) of stroke have focused on European-ancestry populations; however, none has been conducted in African-Americans despite the disproportionately high burden of stroke in this population. The Consortium of Minority Population genome-wide Association Studies of Stroke (COMPASS) was established to identify stroke susceptibility loci in minority populations. Methods Using METAL, we conducted meta-analyses of GWAS in 14,746 African-Americans (1,365 ischemic and 1,592 total stroke cases) from COMPASS, and tested SNPs with P<10−6 for validation in METASTROKE, a consortium of ischemic stroke genetic studies in European-ancestry populations. We also evaluated stroke loci previously identified in European-ancestry
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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stroke prevention strategies Moderate
MICAL2 rs12291066 carriers have 1.45x increased stroke risk; preventive counseling is indicated
discuss cardiovascular risk factors, lifestyle modifications, and medication options for stroke prevention
Screening
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blood pressure and cardiovascular screening Moderate
MICAL2 variant rs12291066 is associated with increased stroke risk (1.45x effect size)
annual blood pressure measurement, consider baseline ECG and lipid panel