rs12286180 - FLRT1, MACROD1

Magnitude 2.0 · 1 study on file

Reported associations

• A combined genome-wide association and molecular study of age-related hearing loss in H. sapiens - BMC medicine (2022) · Liu W, Johansson Å, Rask-Andersen H, Rask-Andersen M · PubMed 34847940

  ABSTRACT: Background Sensorineural hearing loss is one of the most common sensory deficiencies. However, the molecular contribution to age-related hearing loss is not fully elucidated. Methods We performed genome-wide association studies (GWAS) for hearing loss-related traits in the UK Biobank (N = 362,396) and selected a high confidence set of ten hearing-associated gene products for staining in human cochlear samples: EYA4, LMX1A, PTK2/FAK, UBE3B, MMP2, SYNJ2, GRM5, TRIOBP, LMO-7, and NOX4. Results All proteins were found to be expressed in human cochlear structures. Our findings illustrate cochlear structures that mediate mechano-electric transduction of auditory stimuli, neuronal conductance, and neuronal plasticity to be involved in age-related hearing loss. Conclusions Our results su

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