rs12283870 - MRGPRD - MRGPRF

Magnitude 2.8 · 1 study on file

Reported associations

• Association of Inherited Genetic Factors With Drug-Induced Hepatic Damage Among Children With Acute Lymphoblastic Leukemia - Unknown journal (n.d.) · Unknown authors · PubMed 36580335

  ABSTRACT: Key Points Question What are the genetic drivers of interpatient variability in the occurrence of hepatotoxic effects during treatment for acute lymphoblastic leukemia (ALL)? Findings In this genetic association study of 3557 children, adolescents, and young adults receiving ALL therapy, variants in UGT1A1 and PNPLA3 were associated with hyperbilirubinemia and elevated alanine aminotransferase and aspartate aminotransferase levels, respectively. A polygenic risk score-based analysis demonstrated that the UGT1A1 variant was the primary driver of elevated bilirubin levels, while other genetic variants contributed to aminotransferase levels even after adjusting for PNPLA3. Meaning These findings suggest that there is an association between genetic factors and interpatient variabil

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