rs12282281 - SLC22A9

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association meta-analysis for total thyroid hormone levels in Croatian population. - Journal of human genetics (2019) · Gunjača I, Matana A, Boutin T, Torlak V, Punda A, Polašek O, Boraska Perica V, Hayward C, Zemunik T, Barbalić M · PubMed 30824882

  Thyroid hormones (THs) are key regulators of cellular growth, development, and metabolism. The thyroid gland secretes two THs, thyroxine (T4) and triiodothyronine (T3), into the plasma where they are almost all bound reversibly to plasma proteins. Free forms of THs are metabolically active, however, they represent a very small fraction of total TH levels. No genome-wide studies have been performed to date on total TH levels, comprising of protein-bound and free forms of THs. To detect genetic variants associated with total TH levels, we carried out the first GWAS meta-analysis of total T4 levels in 1121 individuals from two Croatian cohorts (Split and Korcula). We also performed GWAS analyses of total T3 levels in 577 individuals and T3/T4 ratio in 571 individuals from the Split cohort. Th

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