rs12277307 - HSD17B12
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures - Unknown journal (n.d.) · Unknown authors · PubMed 40436827
ABSTRACT: Genome-wide association studies (GWAS) have predominantly focused on European ancestry populations, limiting biological discoveries across diverse populations. Here we report GWAS findings from 153,950 individuals across 36 quantitative traits in the Korean Cancer Prevention Study-II (KCPS2) Biobank. We discovered 301 previously unreported genetic loci in KCPS2, including an association between thyroid-stimulating hormone and CD36. Meta-analysis with the Korean Genome and Epidemiology Study, Biobank Japan, Taiwan Biobank, and UK Biobank identified 4588 loci that were not significant in any contributing GWAS. We describe differences in genetic architectures across these East Asian and European samples. We also highlight East Asian specific associations, including a known pleiotrop
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Genetic risk for elevated GGT and liver stress Moderate
This variant predicts 0.012 standard-deviation increase in GGT across 928,679 individuals, suggesting increased monitoring may be warranted.
Discuss GGT levels and liver health at routine visit; consider baseline testing if persistently elevated
Screening
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Annual GGT and liver function testing Moderate
rs12277307-A allele is strongly associated with elevated gamma-glutamyl transferase levels, a marker of oxidative stress and hepatic function.
Include GGT in annual liver panel; threshold for further evaluation if persistently elevated