rs12271785 - LINC02719 - GUCY1A2

Magnitude 4.5 · 1 study on file

Reported associations

• Genetic association study of preterm birth and gestational age in a population-based case-control study in Peru. - Journal of neonatal-perinatal medicine (2024) · Juvinao-Quintero DL, Sanchez SE, Workalemahu T, Pinto N, Liang L, Williams MA, Gelaye B · PubMed 39302385

  Preterm birth (PTB) affects ∼15 million pregnancies worldwide. Genetic studies have identified several candidate loci for PTB, but results remain inconclusive and limited to European populations. Thus, we conducted a genome-wide association study (GWAS) of PTB and gestational age at delivery (GA) among 2,212 Peruvian women. PTB cases delivered≥20 weeks' but < 37 weeks' gestation, while controls delivered at term (≥37 weeks but <42 weeks). Multivariable regressions were used to identify genetic markers for PTB and GA (∼6 million SNPs), adjusting for maternal age and the first two genetic principal components. In silico functional analysis was conducted among top signals detected with an arbitrary P < 1.0×10-5 . We sought to replicate genetic markers for PTB and GA identifi

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