rs12268250 - RPA2P2 - NRG3
Magnitude 4.5 · 1 study on file
Reported associations
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Genetic association study identifies genetic variants for non-alcoholic fatty liver without comorbidities in the Korean population. - Genes & genomics (2023) · Kim YJ, Cho YS · PubMed 37133724
Non-alcoholic fatty liver (NAFL) refers to a disease in which fat builds up in the liver, similar to what occurs for those who drink a lot of alcohol, even in cases of not drinking alcohol at all or only in a small amount. Along with non-alcoholic steatohepatitis (NASH), NAFL is a type of non-alcoholic fatty liver disease (NAFLD). Currently, the prevalence of NAFLD is increasing worldwide. A wide range of comorbidities that can increase the risk of NAFLD includes obesity, type 2 diabetes, dyslipidemia, and metabolic syndrome. This study aimed to discover genetic variants for NAFL in the Korean population. Differing from previous studies, we conducted a genome-wide association study for NAFL in the selected subjects without comorbidities to rule out bias due to the inclusion of confounding
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Genetic NAFLD susceptibility and prevention strategy Moderate
Genetic association with NAFLD risk warrants professional assessment of individual risk factors and monitoring strategy
Establish with provider baseline screening frequency and exclude advanced fibrosis
Screening
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NAFLD assessment and surveillance Moderate
rs12268250 risk allele shows genome-wide significant association with 1.75-fold increased NAFLD susceptibility
Baseline ultrasound or elastography; repeat every 1-2 years if unchanged