rs12265333 - CHUK-DT, CWF19L1

Magnitude 2.2 · 1 study on file

Reported associations

• Causal relationship and shared genetic loci between psoriasis and type 2 diabetes through trans-disease meta-analysis - Unknown journal (n.d.) · Unknown authors · PubMed 33385400

  ABSTRACT: Psoriasis and type 2 diabetes (T2D) are complex conditions with significant impact on health. Psoriasis patients have higher risk of type 2 diabetes (~1.5 Odds Ratio) and vice versa, controlling for body mass index (BMI), yet there has been limited study comparing their genetic architecture. We hypothesized there are shared genetic components between psoriasis and T2D. Trans-disease meta-analysis (TDMA) was applied to 8,016,731 well-imputed genetic markers from large-scale meta-analyses of psoriasis (11,024 cases and 16,336 controls) and T2D adjusted for BMI (74,124 cases and 824,006 controls). We confirmed our findings in a hospital-based study (42,112 patients) and tested for causal relationships with multi-variable Mendelian randomization. Mendelian randomization identified a

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