rs12257692 - PLA2G12B
Magnitude 2.2 · 1 study on file
Reported associations
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Genetics of Blood Lipids Among ~300,000 Multi-Ethnic Participants of the Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 30275531
ABSTRACT: The Million Veteran Program (MVP) was established in 2011 as a national research initiative to determine how genetic variation influences the health of U.S. military veterans. We genotyped 312,571 MVP participants using a custom biobank array and linked the genetic data to laboratory and clinical phenotypes extracted from electronic health records covering a median of 10.0 years of follow-up. Among 297,626 veterans with at least 1 blood lipid measurement including 57,332 blacks and 24,743 Hispanics, we tested up to ~32 million variants for association with lipid levels and identified 118 novel genome-wide significant loci after meta-analysis with data from the Global Lipids Genetics Consortium (total N > 600,000). Through a focus on mutations predicted to result in a loss of gene
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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reduce added sugars and refined carbohydrates Moderate
Refined carbohydrates and sugars elevate triglycerides; relevant for rs12257692-T carriers with genetic predisposition
limit added sugars to less than 10% of daily calories, prioritize whole grains
Exercise
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aerobic exercise for triglyceride management Moderate
Regular aerobic exercise reduces triglycerides; relevant for carriers of rs12257692-T with genetic predisposition
150 minutes moderate-intensity aerobic activity per week
Screening
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triglyceride levels Moderate
rs12257692-T allele associated with elevated triglycerides in large GWAS (n=297,626)
annual lipid panel including fasting triglycerides