Expressive

rs12257301 - OPN4

Magnitude 4.5 · 1 study on file

Reported associations

  • Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease - Unknown journal (n.d.) · Unknown authors · PubMed 27082954

    ABSTRACT: There is a growing literature indicating that genetic variants modify many of the associations between environmental exposures and clinical outcomes, potentially by increasing susceptibility to these exposures. However, genome-scale investigations of these interactions have been rarely performed particularly in the case of air pollution exposures. We performed race-stratified genome-wide gene-environment interaction association studies on European-American (EA, N = 1623) and African-American (AA, N = 554) cohorts to investigate the joint influence of common single nucleotide polymorphisms (SNPs) and residential exposure to traffic ("traffic exposure")-a recognized vascular disease risk factor-on peripheral arterial disease (PAD). Traffic exposure was estimated via the dis

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • peripheral arterial disease risk assessment Moderate

    rs12257301 carriers show increased PAD risk with air pollution exposure; early identification enables preventive strategies

    mention OPN4 variant and air pollution exposure history at next appointment

Lifestyle

  • traffic-related air pollution Moderate

    OPN4 variants affect circadian regulation of cardiovascular function, amplifying PAD risk under air pollution exposure

    reduce commute near highways, use air filters indoors, monitor local AQI

Screening

  • peripheral arterial disease screening Moderate

    rs12257301 carriers have elevated baseline PAD risk, particularly with high air pollution exposure; early detection improves outcomes

    ask doctor about ankle-brachial index testing, especially if air pollution exposure is high