rs12257178 - ADRA2A - BTBD7P2

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide meta-analysis of longitudinal alcohol consumption across youth and early adulthood - Unknown journal (n.d.) · Unknown authors · PubMed 26081443

  ABSTRACT: The public health burden of alcohol is unevenly distributed across the life course, with levels of use, abuse and dependence increasing across adolescence and peaking in early adulthood. Here we leverage this temporal patterning to search for common genetic variants predicting developmental trajectories of alcohol consumption. Comparable psychiatric evaluations measuring alcohol consumption were collected in three, longitudinal community samples (N=2,126, obs=12,166). Consumption repeated measurements spanning adolescence and early adulthood were analyzed using linear mixed models, estimating individual consumption trajectories, which were then tested for association with Illumina 660W-Quad genotype data (866,099 SNPs after imputation and QC). Association results were combined ac

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.