rs12246079 - C10orf90
Magnitude 2.2 · 1 study on file
Reported associations
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Large-scale meta-genome-wide association study reveals common genetic factors linked to radiation-induced acute toxicities across cancer types - Unknown journal (n.d.) · Unknown authors · PubMed 37862240
ABSTRACT: Abstract Background This study was designed to identify common genetic susceptibility and shared genetic variants associated with acute radiation-induced toxicity across 4 cancer types (prostate, head and neck, breast, and lung). Methods A genome-wide association study meta-analysis was performed using 19 cohorts totaling 12 042 patients. Acute standardized total average toxicity (STATacute) was modelled using a generalized linear regression model for additive effect of genetic variants, adjusted for demographic and clinical covariates (rSTATacute). Linkage disequilibrium score regression estimated shared single-nucleotide variation (SNV-formerly SNP)-based heritability of rSTATacute in all patients and for each cancer type. Results Shared SNV-based heritability of STATacut
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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radiation therapy toxicity risk when diagnosed with cancer Moderate
The A risk allele at rs12246079 is associated with increased acute radiotoxicity in cancer patients receiving radiation therapy.
If diagnosed with cancer, inform your oncologist of this genetic variant when considering radiation therapy.