rs12244585 - NEBL

Magnitude 2.0 · 1 study on file

Reported associations

• Validation of lung cancer polygenic risk scores in a high-risk case-control cohort. - Genetics in medicine : official journal of the American College of Medical Genetics (2023) · Lebrett MB, Smith MJ, Crosbie EJ, Bowes J, Byers HJ, Evans DG, Crosbie PAJ · PubMed 37154150

  Screening with low-dose computed tomography reduces lung cancer (LC) mortality. Risk prediction models used for screening selection do not include genetic variables. Here, we investigated the performance of previously published polygenic risk scores (PRSs) for LC, considering their potential to improve screening selection. We validated 9 PRSs in a high-risk case-control cohort, comprising genotype data from 652 surgical patients with LC and 550 cancer-free, high-risk (PLCO score ≥ 1.51%) participants of the Manchester Lung Health Check, a community-based LC screening program (n = 550). Discrimination (area under the curve [AUC]) between cases and controls was assessed for each PRS independently and alongside clinical risk factors. Median age was 67 years, 53% were female, 46% were curre

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