rs1223889 - TRPM1 - LINC03034

Magnitude 2.2 · 1 study on file

Reported associations

• Clinical and Genome-Wide Analysis of Multiple Severe Cisplatin-Induced Neurotoxicities in Adult-Onset Cancer Survivors - Unknown journal (n.d.) · Unknown authors · PubMed 32998964

  ABSTRACT: Purpose: Cisplatin is a first-line chemotherapeutic for many cancers, but causes neurotoxicity including hearing loss, tinnitus, and peripheral sensory neuropathy. However, no study has comprehensively characterized risk factors for developing multiple (>1) severe neurotoxicities. Experimental Design: The relationship between multiple severe neurotoxicities and age, cumulative cisplatin dose, medical history, and lifestyle/behavioral factors was evaluated in 300 cisplatin-treated testicular cancer survivors using logistic regression. Case-control GWAS (cases: 104; controls: 196) was also performed. Results: Age at clinical examination (p=6.4x10−16) and cumulative cisplatin dose (p=5.4x10−4) were positively associated with multiple severe neurotoxicity risk, as were high serum

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