rs1223742 - LINC02775
Magnitude 2.2 · 1 study on file
Reported associations
-
Genome-wide association study and trans-ethnic meta-analysis identify novel susceptibility loci for type 2 diabetes mellitus - Unknown journal (n.d.) · Unknown authors · PubMed 38685053
ABSTRACT: Background The genetic basis of type 2 diabetes (T2D) is under-investigated in the Middle East, despite the rapidly growing disease prevalence. We aimed to define the genetic determinants of T2D in Qatar. Methods Using whole genome sequencing of 11,436 participants (2765 T2D cases and 8671 controls) from the population-based Qatar Biobank (QBB), we conducted a genome-wide association study (GWAS) of T2D with and without body mass index (BMI) adjustment. Results We replicated 93 known T2D-associated loci in a BMI-unadjusted model, while 96 known loci were replicated in a BMI-adjusted model. The effect sizes and allele frequencies of replicated SNPs in the Qatari population generally concurred with those from European populations. We identified a locus specific to our cohort locate
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
-
Increase whole grains, legumes, non-starchy vegetables High
Higher-fiber, lower-glycemic-index foods improve insulin sensitivity and reduce Type 2 diabetes risk.
Make half of grains whole; include legumes or vegetables at each meal
Lifestyle
-
Regular aerobic exercise High
Physical activity improves insulin sensitivity and glucose metabolism, reducing Type 2 diabetes risk in genetically susceptible individuals.
150 minutes of moderate-intensity aerobic exercise per week
Screening
-
Hemoglobin A1c and fasting glucose High
Genetic variant increases Type 2 diabetes risk; regular glucose monitoring enables early detection.
Annual hemoglobin A1c and fasting glucose testing