Expressive

rs1223245 - LEFTY1

Magnitude 2.2 · 2 studies on file

Reported associations

  • A genome-wide association meta-analysis of preschool internalizing problems. - Journal of the American Academy of Child and Adolescent Psychiatry (2015) · Benke KS, Nivard MG, Velders FP, Walters RK, Pappa I, Scheet PA, Xiao X, Ehli EA, Palmer LJ, Whitehouse AJ, Verhulst FC, Jaddoe VW, Rivadeneira F, Groen-Blokhuis MM, van Beijsterveldt CE, Davies GE, Hudziak JJ, Lubke GH, Boomsma DI, Pennell CE, Tiemeier H, Middeldorp CM · PubMed 24839885

    Preschool internalizing problems (INT) are highly heritable and moderately genetically stable from childhood into adulthood. Gene-finding studies are scarce. In this study, the influence of genome-wide measured single nucleotide polymorphisms (SNPs) was investigated in 3 cohorts (total N = 4,596 children) in which INT was assessed with the same instrument, the Child Behavior Checklist (CBCL). First, genome-wide association (GWA) results were used for density estimation and genome-wide complex trait analysis (GCTA) to calculate the variance explained by all SNPs. Next, a fixed-effect inverse variance meta-analysis of the 3 GWA analyses was carried out. Finally, the overlap in results with prior GWA studies of childhood and adulthood psychiatric disorders and treatment responses was tested b

  • Mapping the proteo-genomic convergence of human diseases - Unknown journal (n.d.) · Unknown authors · PubMed 34648354

    ABSTRACT: Characterization of the genetic regulation of proteins is essential for understanding disease etiology and developing therapies. We identified 10,674 genetic associations for 3,892 plasma proteins to create a cis-anchored gene-protein-disease map of 1,859 connections that highlights strong cross-disease biological convergence. This proteo-genomic map provides a framework to 1) connect etiologically related diseases, 2) provide biological context for new or emerging disorders, and 3) integrate different biological domains to establish mechanisms for known gene-disease links. Our results identify proteo-genomic connections within and between diseases and establish the value of cis-protein variants for annotation of likely causal disease genes at GWAS loci, addressing a major barrie

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