Expressive

rs12229918 - MSRB3

Magnitude 2.2 · 4 studies on file

Reported associations

  • Cross-ancestry genome-wide association studies of brain imaging phenotypes. - Nature genetics (2024) · Fu J, Zhang Q, Wang J, Wang M, Zhang B, Zhu W, Qiu S, Geng Z, Cui G, Yu Y, Liao W, Zhang H, Gao B, Xu X, Han T, Yao Z, Qin W, Liu F, Liang M, Wang S, Xu Q, Xu J, Zhang P, Li W, Shi D, Wang C, Lui S, Yan Z, Chen F, Zhang J, Li J, Shen W, Miao Y, Wang D, Xian J, Gao JH, Zhang X, Xu K, Zuo XN, Zhang L, Ye Z, Cheng J, Li MJ, Yu C · PubMed 38811844

    Genome-wide association studies of brain imaging phenotypes are mainly performed in European populations, but other populations are severely under-represented. Here, we conducted Chinese-alone and cross-ancestry genome-wide association studies of 3,414 brain imaging phenotypes in 7,058 Chinese Han and 33,224 white British participants. We identified 38 new associations in Chinese-alone analyses and 486 additional new associations in cross-ancestry meta-analyses at P < 1.46 × 10 for discovery and P < 0.05 for replication. We pooled significant autosomal associations identified by single- or cross-ancestry analyses into 6,443 independent associations, which showed uneven distribution in the genome and the phenotype subgroups. We further divided them into 44 associations with dif

  • Novel Genetic Determinants of Dental Maturation in Children. - Journal of dental research (2023) · Grgic O, Prijatelj V, Dudakovic A, Vucic S, Dhamo B, Trajanoska K, Monnereau C, Zrimsek M, Gautvik KM, Reppe S, Shimizu E, Haworth S, Timpson NJ, Jaddoe VWV, Jarvelin MR, Evans D, Uitterlinden AG, Ongkosuwito EM, van Wijnen AJ, Medina-Gomez C, Rivadeneira F, Wolvius EB · PubMed 36437532

    Dental occlusion requires harmonious development of teeth, jaws, and other elements of the craniofacial complex, which are regulated by environmental and genetic factors. We performed the first genome-wide association study (GWAS) on dental development (DD) using the Demirjian radiographic method. Radiographic assessments from participants of the Generation R Study (primary study population, = 2,793; mean age of 9.8 y) were correlated with ~30 million genetic variants while adjusting for age, sex, and genomic principal components (proxy for population stratification). Variants associated with DD at genome-wide significant level ( < 5 × 10 ) mapped to 16q12.2 ( ) (lead variant rs3922616, = 0.16; = 2.2 × 10 ). We used Fisher's combined probability tests weighted by samp

  • Common variants contribute to intrinsic human brain functional networks. - Nature genetics (2022) · Zhao B, Li T, Smith SM, Xiong D, Wang X, Yang Y, Luo T, Zhu Z, Shan Y, Matoba N, Sun Q, Yang Y, Hauberg ME, Bendl J, Fullard JF, Roussos P, Lin W, Li Y, Stein JL, Zhu H · PubMed 35393594

    The human brain forms functional networks of correlated activity, which have been linked with both cognitive and clinical outcomes. However, the genetic variants affecting brain function are largely unknown. Here, we used resting-state functional magnetic resonance images from 47,276 individuals to discover and validate common genetic variants influencing intrinsic brain activity. We identified 45 new genetic regions associated with brain functional signatures (P < 2.8 × 10 ), including associations to the central executive, default mode, and salience networks involved in the triple-network model of psychopathology. A number of brain activity-associated loci colocalized with brain disorders (e.g., the APOE ε4 locus with Alzheimer's disease). Variation in brain function was geneti

  • Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances - Unknown journal (n.d.) · Unknown authors · PubMed 23704328

    ABSTRACT: Twin and family studies indicate that the timing of primary tooth eruption is highly heritable, with estimates typically exceeding 80%. To identify variants involved in primary tooth eruption, we performed a population-based genome-wide association study of 'age at first tooth' and 'number of teeth' using 5998 and 6609 individuals, respectively, from the Avon Longitudinal Study of Parents and Children (ALSPAC) and 5403 individuals from the 1966 Northern Finland Birth Cohort (NFBC1966). We tested 2 446 724 SNPs imputed in both studies. Analyses were controlled for the effect of gestational age, sex and age of measurement. Results from the two studies were combined using fixed effects inverse variance meta-analysis. We identified a total of 15 independent loci, with 10 loci

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