rs12226698 - RIC8A
Magnitude 2.2 · 1 study on file
Reported associations
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Insights into the genetic basis of retinal detachment - Unknown journal (n.d.) · Unknown authors · PubMed 31816047
ABSTRACT: Abstract Retinal detachment (RD) is a serious and common condition, but genetic studies to date have been hampered by the small size of the assembled cohorts. In the UK Biobank data set, where RD was ascertained by self-report or hospital records, genetic correlations between RD and high myopia or cataract operation were, respectively, 0.46 (SE = 0.08) and 0.44 (SE = 0.07). These correlations are consistent with known epidemiological associations. Through meta-analysis of genome-wide association studies using UK Biobank RD cases (N = 3 977) and two cohorts, each comprising ~1 000 clinically ascertained rhegmatogenous RD patients, we uncovered 11 genome-wide significant association signals. These are near or within ZC3H11B, BMP3, COL22A1, DLG5, PLCE1, EFEMP2, TYR, F
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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vision screening for early cataract detection Moderate
rs12226698 in RIC8A is associated with increased cataract surgery risk, possibly through altered BET1L expression in ocular tissues
Annual comprehensive eye exams starting at age 40, or earlier if family history of cataracts