rs12225230 - SIK3
Magnitude 2.2 · 1 study on file
Reported associations
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A large electronic health record-based genome-wide study of serum lipids - Unknown journal (n.d.) · Unknown authors · PubMed 29507422
ABSTRACT: A genome-wide association study of 94,674 multi-ethnic Kaiser Permanente members utilizing 478,866 longitudinal untreated serum lipid electronic-health-record-derived measurements (EHRs) empowered multiple novel findings: 121 new SNP associations (46 primary, 15 conditional, 60 in meta-analysis with Global Lipids Genetic Consortium); increase of 33-42% in variance explained with multiple measurements; sex differences in genetic impact (greater in females for LDL, HDL, TC, the opposite for TG); differences in variance explained amongst non-Hispanic whites, Latinos, African Americans, and East Asians; genetic dominance and epistasis, with strong evidence for both at ABOxFUT2 for LDL; and eQTL tissue-enrichment implicating the liver, adipose, and pancreas. Utilizing EHR pharmacy dat
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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lipid panel (HDL and total cholesterol) High
rs12225230-G increases APOA1 expression in cardiac tissue, associated with higher HDL and total cholesterol levels across large populations
obtain lipid panel to confirm genotype-phenotype correlation; if normal, repeat every 5 years