rs12219125 - PLXDC2 - AMD1P1

Magnitude 2.0 · 1 study on file

Reported associations

• Genome-wide association study of diabetic retinopathy in a Taiwanese population. - Ophthalmology (2011) · Huang YC, Lin JM, Lin HJ, Chen CC, Chen SY, Tsai CH, Tsai FJ · PubMed 21310492

  Diabetic retinopathy (DR) is a microvascular complication of diabetes with a complex multifactorial pathogenesis. The aim of this study was to identify the susceptibility genes that increase the risk of DR in type 2 diabetes (T2D) and to further elucidate the underlying mechanism of DR pathogenesis. A case-control study. We included 749 unrelated individuals with T2D (174 with DR and 575 without DR) and 100 nondiabetic controls. We conducted a genome-wide association study using Illumina HumanHap550-Duo BeadChips. Compared with the genotypic distribution of single nucleotide polymorphisms (SNPs) between subjects with DR and without DR. Using statistical models, we selected a total of 12 SNPs with P-values <1 × 10(-6) that were associated with DR. After controlling for diabetes duration an

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