rs12218524 - LINC02624 - RPL23AP59

Magnitude 2.2 · 1 study on file

Reported associations

• Sex and statin-related genetic associations at the PCSK9 gene locus: results of genome-wide association meta-analysis - Unknown journal (n.d.) · Unknown authors · PubMed 38532495

  ABSTRACT: Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key player of lipid metabolism with higher plasma levels in women throughout their life. Statin treatment affects PCSK9 levels also showing evidence of sex-differential effects. It remains unclear whether these differences can be explained by genetics. Methods We performed genome-wide association meta-analyses (GWAS) of PCSK9 levels stratified for sex and statin treatment in six independent studies of Europeans (8936 women/11,080 men respectively 14,825 statin-free/5191 statin-treated individuals). Loci associated in one of the strata were tested for statin- and sex-interactions considering all independent signals per locus. Independent variants at the PCSK9 gene locus were then used in a stratified Mendelian R

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