Expressive

rs12215012 - HNRNPA1P1 - CD83P1

Magnitude 2.2 · 1 study on file

Reported associations

  • Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank. - Hernia : the journal of hernias and abdominal wall surgery (2022) · Wei J, Attaar M, Shi Z, Na R, Resurreccion WK, Haggerty SP, Zheng SL, Helfand BT, Ujiki MB, Xu J · PubMed 34382107

    Familial aggregation is known for both hernia development and recurrence. To date, only one genome-wide association study (GWAS) limited to inguinal hernia has been reported that identified four risk-associated loci. We aim to investigate polygenic architecture of abdominal wall hernia development and recurrence. A GWAS was performed in 367,394 subjects from the UK Biobank to investigate the polygenic architecture of abdominal wall hernia subtypes (inguinal, femoral, umbilical, ventral) and identify specific single nucleotide polymorphisms (SNPs) that are associated with their risk. Expression quantitative trait loci (eQTL) analysis was performed to identify genes whose expression levels are associated with these SNPs. A genetic risk score (GRS) was used to assess the cumulative effect of

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Exercise

  • proper lifting and straining techniques Moderate

    improper technique with lifting or straining raises intra-abdominal pressure acutely

    bend knees not back when lifting; avoid Valsalva maneuver; consult trainer for form if needed

    • GWAS_CATALOG:34382107

Lifestyle

  • maintain healthy body weight Moderate

    excess abdominal weight increases intra-abdominal pressure, increasing hernia risk

    maintain BMI 18.5-24.9; discuss with doctor if weight management needed

    • GWAS_CATALOG:34382107

Screening

  • periodic screening for inguinal hernia Moderate

    genetic variant increases inguinal hernia risk; earlier detection may improve outcomes

    self-examine for groin bulges or pain monthly, discuss with doctor if symptoms develop

    • GWAS_CATALOG:34382107