Expressive

rs12214216 - ADGRG6 - HIVEP2

Magnitude 4.5 · 1 study on file

Reported associations

  • Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk - Unknown journal (n.d.) · Unknown authors · PubMed 36914875

    ABSTRACT: Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 588,452 participants, we identified 1,020 independent association signals implicating 559 genes supported by ≥2 criteria from a systematic variant-to-gene mapping framework. These genes were enriched in 29 pathways. Individual variants showed heterogeneity across ancestries, age and smoking groups, and collectively as a genetic risk score showed strong association with COPD across ancestry groups. We undertook phenome-wide association studies for selected associated variants as well as trait and pathway-specific genetic risk scores to infer possible consequences of interve

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Exercise

  • regular aerobic exercise Moderate

    Aerobic conditioning improves lung function and can help optimize respiratory capacity in context of genetic predisposition.

    Aim for 150 minutes moderate-intensity aerobic activity per week

Lifestyle

  • smoking and air pollution exposure Moderate

    Genetic predisposition to lower lung function makes environmental exposures more consequential for long-term respiratory health.

    Complete smoking cessation if applicable; minimize secondhand smoke and air pollution

Screening

  • pulmonary function testing Moderate

    Genetic variation in rs12214216 associates with lower FEV1/FVC ratio, indicating reduced lung function.

    Baseline spirometry; reassess every 3-5 years or if respiratory symptoms develop