rs12214118 - SAYSD1 - KCNK5
Magnitude 2.2 · 1 study on file
Reported associations
-
Urate, Blood Pressure, and Cardiovascular Disease - Unknown journal (n.d.) · Unknown authors · PubMed 33356394
ABSTRACT: Supplemental Digital Content is available in the text. Serum urate has been implicated in hypertension and cardiovascular disease, but it is not known whether it is exerting a causal effect. To investigate this, we performed Mendelian randomization analysis using data from UK Biobank, Million Veterans Program and genome-wide association study consortia, and meta-analysis of randomized controlled trials. The main Mendelian randomization analyses showed that every 1-SD increase in genetically predicted serum urate was associated with an increased risk of coronary heart disease (odds ratio, 1.19 [95% CI, 1.10-1.30]; P=4×10−5), peripheral artery disease (1.12 [95% CI, 1.03-1.21]; P=9×10−3), and stroke (1.11 [95% CI, 1.05-1.18]; P=2×10−4). In Mendelian randomization med
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
-
serum uric acid level Moderate
rs12214118-A allele associates with elevated uric acid, increasing gout and chronic kidney disease risk
Annual serum uric acid testing; if persistently >6.8 mg/dL, discuss gout prophylaxis with physician
Diet
-
limit high-purine foods Moderate
Dietary purines are converted to uric acid; reduction may mitigate genetic elevation risk
Limit purine-rich foods (red meat, organ meats, high-fructose beverages) to 1-2 times weekly
Discuss with your doctor
-
genetic predisposition to elevated uric acid and gout risk Moderate
Clinician assessment of individual gout risk factors and need for monitoring or prophylaxis