rs12211694 - GNG5P1 - PRR18
Magnitude 4.5 · 1 study on file
Reported associations
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Nutrigenetic Interactions Might Modulate the Antioxidant and Anti-Inflammatory Status in Mastiha-Supplemented Patients With NAFLD - Unknown journal (n.d.) · Unknown authors · PubMed 34025683
ABSTRACT: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease with no therapeutic consensus. Oxidation and inflammation are hallmarks in the progression of this complex disease, which also involves interactions between the genetic background and the environment. Mastiha is a natural nutritional supplement known to possess antioxidant and anti-inflammatory properties. This study investigated how a 6-month Mastiha supplementation (2.1 g/day) could impact the antioxidant and inflammatory status of patients with NAFLD, and whether genetic variants significantly mediate these effects. We recruited 98 patients with obesity (BMI ≥ 30 kg/m2) and NAFLD and randomly allocated them to either the Mastiha or the placebo group for 6 months. The anti-oxidative and inflammatory st
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Supplements
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Mastiha supplementation (Pistacia lentiscus) Moderate
A allele carriers show enhanced metabolic response to Mastiha with decreased hemoglobin reflecting reduced mitochondrial oxidative stress, which is protective in fatty liver disease.
2.1g daily (3 capsules of 0.35g each) for 6 months minimum