rs12210419 - RNA5SP215 - COX6A1P3
Magnitude 2.2 · 1 study on file
Reported associations
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A large-scale genomic investigation of susceptibility to infection and its association with mental disorders in the Danish population - Unknown journal (n.d.) · Unknown authors · PubMed 31712607
ABSTRACT: Infections and mental disorders are two of the major global disease burdens. While correlations between mental disorders and infections have been reported, the possible genetic links between them have not been assessed in large-scale studies. Moreover, the genetic basis of susceptibility to infection is largely unknown, as large-scale genome-wide association studies of susceptibility to infection have been lacking. We utilized a large Danish population-based sample (N = 65,534) linked to nationwide population-based registers to investigate the genetic architecture of susceptibility to infection (heritability estimation, polygenic risk analysis, and a genome-wide association study (GWAS)) and examined its association with mental disorders (comorbidity analysis and genetic corr
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic predisposition to hospital-contact infections Moderate
Genetic variant associated with increased hospital contact for infections; personalized prevention strategy discussion is warranted
Lifestyle
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rigorous infection prevention practices Moderate
Genetic predisposition to serious infections; enhanced hygiene and vaccination may reduce hospitalization risk
Maintain hand hygiene, annual vaccination review (flu, pneumococcal)