rs12209106 - FOXC1 - GMDS
Magnitude 2.2 · 1 study on file
Reported associations
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Interethnic analyses of blood pressure loci in populations of East Asian and European descent - Unknown journal (n.d.) · Unknown authors · PubMed 30487518
ABSTRACT: Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Blood pressure management strategy and cardiovascular risk Moderate
Genetic predisposition to elevated diastolic blood pressure warrants proactive discussion of individual CVD risk and prevention options
Screening
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Blood pressure screening Moderate
rs12209106-T allele is associated with higher diastolic blood pressure (effect 0.28 mmHg per allele, p=6.4e-9) in large, replicated genome-wide studies
Annual blood pressure screening; increase frequency if baseline BP elevated