rs12208899 - MTCYBP4 - EYA4
Magnitude 2.2 · 1 study on file
Reported associations
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Multi-Ethnic Genome-wide Association Study for Atrial Fibrillation - Unknown journal (n.d.) · Unknown authors · PubMed 29892015
ABSTRACT: Atrial fibrillation (AF) affects over 33 million individuals worldwide and has a complex heritability. We conducted the largest meta-analysis of genome-wide association studies for AF to date, consisting of over half a million individuals including 65,446 with AF. In total, we identified 97 loci significantly associated with AF including 67 of which were novel in a combined-ancestry analysis, and 3 in a European specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait loci (eQTL) analyses in 101 left atrial samples, the most relevant tissue for AF. We also performed transcriptome-wide analyses that identified 57 AF-associated genes, 42 of which overlap with GWAS loci. The identified loci implicate
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic risk for atrial fibrillation Moderate
Carrier of genetic variant associated with increased AF risk; requires clinical risk assessment, baseline cardiac evaluation, and discussion of risk mitigation strategies
Screening
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atrial fibrillation screening and monitoring Moderate
Genetic variant increases atrial fibrillation risk by approximately 5 percent; baseline and periodic screening may prevent undiagnosed paroxysmal AF
Consult with cardiologist about ECG screening or ambulatory monitoring strategy given genetic risk