rs12206488 - NUFIP1P1 - RNU7-66P

Magnitude 2.2 · 1 study on file

Reported associations

• Genetic analysis of endometriosis and depression identifies shared loci and implicates causal links with gastric mucosa abnormality. - Human genetics (2021) · Adewuyi EO, Mehta D, Sapkota Y, Auta A, Yoshihara K, Nyegaard M, Griffiths LR, Montgomery GW, Chasman DI, Nyholt DR · PubMed 32959083

  Evidence from observational studies indicates that endometriosis and depression often co-occur. However, conflicting evidence exists, and the etiology as well as biological mechanisms underlying their comorbidity remain unknown. Utilizing genome-wide association study (GWAS) data, we comprehensively assessed the relationship between endometriosis and depression. Single nucleotide polymorphism effect concordance analysis (SECA) found a significant genetic overlap between endometriosis and depression (P = 9.99 × 10 ). Linkage disequilibrium score regression (LDSC) analysis estimated a positive and highly significant genetic correlation between the two traits (r = 0.27, P = 8.85 × 10 ). A meta-analysis of endometriosis and depression GWAS (sample size = 709,111), identif

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.