rs12205186 - LINC02534 - FRK
Magnitude 2.2 · 1 study on file
Reported associations
-
DSP variants may be associated with longitudinal change in quantitative emphysema - Unknown journal (n.d.) · Unknown authors · PubMed 31324189
ABSTRACT: Background Emphysema, characterized by lung destruction, is a key component of Chronic Obstructive Pulmonary Disease (COPD) and is associated with increased morbidity and mortality. Genome-wide association studies (GWAS) have identified multiple genetic factors associated with cross-sectional measures of quantitative emphysema, but the genetic determinants of longitudinal change in quantitative measures of emphysema remain largely unknown. Our study aims to identify genetic variants associated with longitudinal change in quantitative emphysema measured by computed tomography (CT) imaging. Methods We included current and ex-smokers from two longitudinal cohorts: COPDGene, a study of Non-Hispanic Whites (NHW) and African Americans (AA), and the Evaluation of COPD Longitudinally to
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
-
tobacco smoke exposure Moderate
The A allele at rs12205186 associates with 0.1 unit per year faster lung density decline in smokers, increasing emphysema risk
If currently smoking, prioritize cessation programs; minimize all tobacco and passive smoke exposure
Screening
-
lung function and emphysema progression Moderate
The A allele associates with faster lung density decline in smokers, warranting closer surveillance for emphysema development
Annual spirometry and chest imaging for current and former smokers with significant history