rs12203328 - RNU6-1060P - SPTLC1P2

Magnitude 2.2 · 1 study on file

Reported associations

• Identification of common genetic risk variants for autism spectrum disorder - Unknown journal (n.d.) · Unknown authors · PubMed 30804558

  ABSTRACT: Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants contribute substantially to ASD susceptibility, but to date no individual variants have been robustly associated with ASD. With a marked sample size increase from a unique Danish population resource, we report a genome-wide association meta-analysis of 18,381 ASD cases and 27,969 controls that identifies five genome-wide significant loci. Leveraging GWAS results from three phenotypes with significantly overlapping genetic architectures (schizophrenia, major depression, and educational attainment), seven additional loci shared with other traits are identified at equally strict significance levels. Dissecting th

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