Expressive

rs12196992 - LINC01016

Magnitude 2.2 · 1 study on file

Reported associations

  • Association of SUMOylation Pathway Genes With Stroke in a Genome-Wide Association Study in India. - Neurology (2021) · Kumar A, Chauhan G, Sharma S, Dabla S, Sylaja PN, Chaudhary N, Gupta S, Agrawal CS, Anand KS, Srivastava AK, Vibha D, Sagar R, Raj R, Maheshwari A, Vivekanandhan S, Kaul B, Raghavan S, Gorthi SP, Mohania D, Kaushik S, Yadav RK, Hazarika A, Sharma P, Prasad K · PubMed 34031191

    To undertake a genome-wide association study (GWAS) to identify genetic variants for stroke in an Indian population. In a hospital-based case-control study, 8 teaching hospitals in India recruited 4,088 participants, including 1,609 stroke cases. Imputed genetic variants were tested for association with stroke subtypes using both single-marker and gene-based tests. Association with vascular risk factors was performed with logistic regression. Various databases were searched for replication, functional annotation, and association with related traits. Status of candidate genes previously reported in the Indian population was also checked. Associations of vascular risk factors with stroke were similar to previous reports and show modifiable risk factors such as hypertension, smoking, and alco

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Stroke risk assessment and primary prevention strategy Moderate

    rs12196992 in LINC01016 is associated with significantly increased cardioembolic stroke risk

    Schedule consultation with cardiologist or stroke prevention specialist to review individual risk

Screening

  • Atrial fibrillation screening Moderate

    Cardioembolic stroke is typically caused by cardiac arrhythmias like atrial fibrillation which can be detected and managed

    Baseline ECG and discuss with cardiologist regarding extended cardiac monitoring if indicated

  • Blood pressure monitoring Moderate

    Hypertension is a key modifiable risk factor for all stroke types including cardioembolic

    Check blood pressure regularly and follow provider recommendations for monitoring frequency