rs12196819 - ARMC2 - SESN1

Magnitude 2.2 · 1 study on file

Reported associations

• Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata - Unknown journal (n.d.) · Unknown authors · PubMed 36726022

  ABSTRACT: Uterine leiomyomata (UL) are the most common tumours of the female genital tract and the primary cause of surgical removal of the uterus. Genetic factors contribute to UL susceptibility. To add understanding to the heritable genetic risk factors, we conduct a genome-wide association study (GWAS) of UL in up to 426,558 European women from FinnGen and a previous UL meta-GWAS. In addition to the 50 known UL loci, we identify 22 loci that have not been associated with UL in prior studies. UL-associated loci harbour genes enriched for development, growth, and cellular senescence. Of particular interest are the smooth muscle cell differentiation and proliferation-regulating genes functioning on the myocardin-cyclin dependent kinase inhibitor 1 A pathway. Our results further suggest t

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