Expressive

rs12195339 - SUPT3H

Magnitude 2.2 · 1 study on file

Reported associations

  • Translational genomics of osteoarthritis in 1,962,069 individuals - Unknown journal (n.d.) · Unknown authors · PubMed 40205036

    ABSTRACT: Osteoarthritis is the third most rapidly growing health condition associated with disability, after dementia and diabetes. By 2050, the total number of patients with osteoarthritis is estimated to reach 1 billion worldwide. As no disease-modifying treatments exist for osteoarthritis, a better understanding of disease aetiopathology is urgently needed. Here we perform a genome-wide association study meta-analyses across up to 489,975 cases and 1,472,094 controls, establishing 962 independent associations, 513 of which have not been previously reported. Using single-cell multiomics data, we identify signal enrichment in embryonic skeletal development pathways. We integrate orthogonal lines of evidence, including transcriptome, proteome and epigenome profiles of primary joint tiss

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Exercise

  • high-impact activities that stress hip and knee joints Moderate

    High-impact activities place excessive biomechanical stress on weight-bearing joints, particularly problematic in individuals with genetic predisposition to osteoarthritis

    avoid high-impact sports (running, basketball, tennis); modify with joint-protective techniques

  • regular low-impact exercise for joint health Moderate

    Regular low-impact activity maintains cartilage nutrition, muscle strength, and joint stability, potentially delaying osteoarthritis onset

    150 minutes per week of low-impact activity (swimming, cycling, walking)

Lifestyle

  • maintain healthy weight for joint protection Moderate

    Excess weight increases biomechanical load on hip and knee joints, particularly important given genetic predisposition to osteoarthritis

    maintain BMI in healthy range (18.5-24.9) or per healthcare provider recommendation

Screening

  • early osteoarthritis screening with healthcare provider Moderate

    Genetic variant rs12195339 is strongly associated with osteoarthritis of hip or knee requiring joint replacement

    discuss timing of baseline imaging by age 40, then follow per provider recommendations