rs12193769 - PNLDC1 - MAS1
Magnitude 2.2 · 1 study on file
Reported associations
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Genetics of 35 blood and urine biomarkers in the UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 33462484
ABSTRACT: Clinical laboratory tests are a critical component of the continuum of care. We evaluate the genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n=363,228 individuals). We identify 1,857 loci associated with at least one trait, containing 3,374 fine-mapped associations, and additional sets of large-effect (> 0.1 sd) protein-altering, HLA, and copy-number variant associations. Through Mendelian Randomization analysis, we discover 51 causal relationships, including previously known agonistic effects of urate on gout and cystatin C on stroke. Finally, we develop polygenic risk scores for each biomarker and built 'multi-PRS' models for diseases using 35 PRSs simultaneously, which improved chronic kidney disease, type 2 diabetes, gout, and alcoholic cirr
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Lipoprotein(a) management and cardiovascular risk strategy Moderate
Genetic association with elevated Lp(a) requires discussion of appropriate cardiovascular risk assessment and management.
Discuss Lp(a) level interpretation, cardiovascular risk assessment, and management options.
Screening
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Lipoprotein(a) levels and cardiovascular risk Moderate
Variant is strongly associated with elevated Lipoprotein(a), a genetic cardiovascular risk factor independent of LDL cholesterol.
Obtain baseline Lp(a) measurement if not already done; monitor per healthcare provider.