rs12191817 - AHI1-DT
Magnitude 2.2 · 1 study on file
Reported associations
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Genetic analysis of over half a million people characterises C-reactive protein loci - Unknown journal (n.d.) · Unknown authors · PubMed 35459240
ABSTRACT: Chronic low-grade inflammation is linked to a multitude of chronic diseases. We report the largest genome-wide association study (GWAS) on C-reactive protein (CRP), a marker of systemic inflammation, in UK Biobank participants (N = 427,367, European descent) and the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium (total N = 575,531 European descent). We identify 266 independent loci, of which 211 are not previously reported. Gene-set analysis highlighted 42 gene sets associated with CRP levels (p ≤ 3.2 ×10−6) and tissue expression analysis indicated a strong association of CRP related genes with liver and whole blood gene expression. Phenome-wide association study identified 27 clinical outcomes associated with genetically determi
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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cardiovascular health and CRP management strategy Moderate
Elevated CRP from this variant is an independent risk factor; personalized management should be discussed with healthcare provider
Lifestyle
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anti-inflammatory dietary and lifestyle pattern Low
SNP associated with elevated CRP; anti-inflammatory approaches are known to reduce CRP levels
Mediterranean-style diet, regular exercise, stress management, adequate sleep
Screening
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C-reactive protein levels Moderate
Genetic variant associated with elevated CRP; CRP is an independent biomarker for cardiovascular and inflammatory risk
Measure CRP annually or per clinician guidance