Expressive

rs12187898 - NIHCOLE - RNU6-334P

Magnitude 2.2 · 2 studies on file

Reported associations

  • Overlapping common genetic architecture between major depressive disorders and anxiety and stress-related disorders. - Progress in neuro-psychopharmacology & biological psychiatry (2022) · Mei L, Gao Y, Chen M, Zhang X, Yue W, Zhang D, Yu H · PubMed 34634379

    Major depressive disorders (MDDs) and anxiety and stress-related disorders (ASRDs) have overlapping symptoms and high rates of comorbidity. However, the underlying mechanisms remain largely unknown. Here, we aimed to examine whether MDD and ASRD share genetic risk factors utilizing recent large-scale genome-wide association studies (GWASs). To examine the genetic overlap between MDD and ASRD, we applied genetic correlation analysis to analyze GWAS summary statistics for MDD (16,823 cases and 25,632 controls) and ASRD (12,665 cases and 19,225 controls). We found positive and significant genetic correlations between MDD and ASRD (GNOVA: rho = 0.59, se = 0.01, P = 5.32 × 10 ). Our latent causal variable (LCV) analysis indicated the genetic correlation result from pleiotropic effects

  • Multi-trait analysis of genome-wide association summary statistics using MTAG - Unknown journal (n.d.) · Unknown authors · PubMed 29292387

    ABSTRACT: We introduce Multi-Trait Analysis of GWAS (MTAG), a method for joint analysis of summary statistics from GWASs of different traits, possibly from overlapping samples. We apply MTAG to summary statistics for depressive symptoms (Neff = 354,862), neuroticism (N = 168,105), and subjective well-being (N = 388,538). Compared to 32, 9, and 13 genome-wide significant loci in the single-trait GWASs (most of which are themselves novel), MTAG increases the number of loci to 64, 37, and 49, respectively. Moreover, association statistics from MTAG yield more informative bioinformatics analyses and increase variance explained by polygenic scores by approximately 25%, matching theoretical expectations. FULL TEXT: [INTRO] INTRODUCTION [INTRO] The standard approach in genetic-association studi

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • genetic risk for depression and stress-related disorders Moderate

    GWAS evidence associates this SNP with major depressive disorder and stress-related disorder risk.

    Discuss baseline mental health status and monitoring plan with healthcare provider.

Lifestyle

  • stress management and mood support Moderate

    Association with stress-related disorders and lower subjective well-being suggests benefit from proactive stress-reduction and mood-support practices.

    Regular stress-management practice: meditation, yoga, counseling, or exercise.

Screening

  • mood and depressive symptoms Moderate

    Increased genetic risk for depression warrants proactive symptom monitoring.

    Regular self-assessment or clinical screening for mood changes and depressive symptoms.