rs12174151 - PPP1R10

Magnitude 2.2 · 1 study on file

Reported associations

• A genome-wide association study based on the China Kadoorie Biobank identifies genetic associations between snoring and cardiometabolic traits - Unknown journal (n.d.) · Unknown authors · PubMed 38461358

  ABSTRACT: Despite the high prevalence of snoring in Asia, little is known about the genetic etiology of snoring and its causal relationships with cardiometabolic traits. Based on 100,626 Chinese individuals, a genome-wide association study on snoring was conducted. Four novel loci were identified for snoring traits mapped on SLC25A21, the intergenic region of WDR11 and FGFR, NAA25, ALDH2, and VTI1A, respectively. The novel loci highlighted the roles of structural abnormality of the upper airway and craniofacial region and dysfunction of metabolic and transport systems in the development of snoring. In the two-sample bi-directional Mendelian randomization analysis, higher body mass index, weight, and elevated blood pressure were causal for snoring, and a reverse causal effect was observed b

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