rs12156306 - SLC30A8 - MED30
Magnitude 2.2 · 1 study on file
Reported associations
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Genetics of 35 blood and urine biomarkers in the UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 33462484
ABSTRACT: Clinical laboratory tests are a critical component of the continuum of care. We evaluate the genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n=363,228 individuals). We identify 1,857 loci associated with at least one trait, containing 3,374 fine-mapped associations, and additional sets of large-effect (> 0.1 sd) protein-altering, HLA, and copy-number variant associations. Through Mendelian Randomization analysis, we discover 51 causal relationships, including previously known agonistic effects of urate on gout and cystatin C on stroke. Finally, we develop polygenic risk scores for each biomarker and built 'multi-PRS' models for diseases using 35 PRSs simultaneously, which improved chronic kidney disease, type 2 diabetes, gout, and alcoholic cirr
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Diabetes risk assessment with SLC30A8 variant carrier status Moderate
rs12156306 A allele is associated with higher glucose and HbA1c; discussing individual risk factors allows physician to recommend personalized prevention strategies
Screening
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HbA1c and fasting glucose levels Moderate
rs12156306 A allele carriers show higher glycated hemoglobin and fasting glucose in large GWAS studies, indicating impaired glucose regulation
Obtain baseline HbA1c and fasting glucose; repeat annually per standard diabetes screening guidelines