Expressive

rs12155428 - SDK1

Magnitude 2.2 · 1 study on file

Reported associations

  • A genome-wide association study of tinnitus reveals shared genetic links to neuropsychiatric disorders - Unknown journal (n.d.) · Unknown authors · PubMed 36581688

    ABSTRACT: Tinnitus, a phantom perception of sound in the absence of any external sound source, is a prevalent health condition often accompanied by psychiatric comorbidities. Recent genome-wide association studies (GWAS) highlighted a polygenic nature of tinnitus susceptibility. A shared genetic component between tinnitus and psychiatric conditions remains elusive. Here we present a GWAS using the UK Biobank to investigate the genetic processes linked to tinnitus and tinnitus-related distress, followed by gene-set enrichment analyses. The UK Biobank sample comprised 132,438 individuals with tinnitus and genotype data. Among the study sample, 38,525 individuals reported tinnitus, and 26,889 participants mentioned they experienced tinnitus-related distress in daily living. The genome-wide as

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • psychiatric screening for depression, anxiety, and stress-related disorders Moderate

    Tinnitus and psychiatric conditions share genetic architecture; psychiatric comorbidities present in ~50 percent of clinical tinnitus patients and modify tinnitus-related distress

    Discuss baseline screening for depression and anxiety during annual health assessment

Lifestyle

  • prolonged high-volume recreational music exposure Moderate

    rs12155428-C confers increased tinnitus susceptibility; recreational loud music (>3 h/week at high volume) increases risk (OR 1.88, p<10e-10)

    Limit high-volume music listening to under 3 h/week; use hearing protection when exceeding this

  • unprotected occupational noise exposure Moderate

    rs12155428-C variant increases genetic susceptibility to tinnitus; occupational noise exposure significantly elevates risk (OR 2.14, p<10e-10)

    Use hearing protection (earplugs or earmuffs rated for 85+ dB) in noisy work environments

Screening

  • audiological assessment and tinnitus symptom monitoring Moderate

    rs12155428-C in SDK1 associated with tinnitus (p=7.72e-7, n=132438); early identification enables intervention

    Baseline hearing evaluation; annual screening or sooner if new ear noises develop