rs12149862 - CYB5B

Magnitude 2.0 · 1 study on file

Reported associations

• Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study. - American journal of hypertension (2015) · Sung YJ, de las Fuentes L, Schwander KL, Simino J, Rao DC · PubMed 25189868

  Cardiovascular diseases are among the most significant health problems in the United States. Blood pressure (BP) variability has a genetic component, and most of the genetic variance remains to be identified. One promising strategy for gene discovery is genome-wide analysis of interactions between single nucleotide polymorphisms (SNPs) and environmental factors related to cardiovascular diseases. We investigated SNP-smoking interaction effects on BP in genome-wide data in 6,889 participants from the Framingham Heart Study. We performed the standard 1 degree of freedom (df) test of the interaction effect and the joint 2 df test of main and interaction effects. Three smoking measures were used: cigarettes per day (CPD), pack years of smoking, and smoking status. We identified 7 significant a

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