Expressive

rs12149498 - PIGQ

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways. - Nature genetics (2022) · Watanabe K, Jansen PR, Savage JE, Nandakumar P, Wang X, Hinds DA, Gelernter J, Levey DF, Polimanti R, Stein MB, Van Someren EJW, Smit AB, Posthuma D · PubMed 35835914

    Insomnia is a heritable, highly prevalent sleep disorder for which no sufficient treatment currently exists. Previous genome-wide association studies with up to 1.3 million subjects identified over 200 associated loci. This extreme polygenicity suggested that many more loci remain to be discovered. The current study almost doubled the sample size to 593,724 cases and 1,771,286 controls, thereby increasing statistical power, and identified 554 risk loci (including 364 novel loci). To capitalize on this large number of loci, we propose a novel strategy to prioritize genes using external biological resources and functional interactions between genes across risk loci. Of all 3,898 genes naively implicated from the risk loci, we prioritize 289 and find brain-tissue expression spec

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • genetic insomnia risk and sleep patterns Moderate

    Carriers of rs12149498-T have increased insomnia susceptibility; clinical assessment enables appropriate management

    discuss personal sleep history, family sleep history, and timing of any sleep symptoms with clinician

Exercise

  • regular aerobic exercise Moderate

    Physical activity improves sleep architecture and quality, with timed exercise avoiding sleep disruption

    aim for 150 minutes moderate aerobic activity per week, completed before mid-afternoon

Lifestyle

  • sleep hygiene optimization Moderate

    Consistent sleep schedules and controlled sleep environment improve sleep quality and are first-line insomnia interventions

    establish consistent sleep schedule, maintain cool dark bedroom (60-67F), no screens 1 hour before bed

Screening

  • insomnia symptom monitoring Moderate

    rs12149498-T is associated with increased insomnia risk in large GWAS cohort (n=2.3M, p=5.00e-10)

    track sleep quality, sleep onset latency, nighttime awakenings, and daytime fatigue