rs12149074 - LINC01228 - DYNLRB2-AS1

Magnitude 4.5 · 1 study on file

Reported associations

• A Genome-wide Association Study of Bipolar Disorder with Comorbid Eating Disorder Replicates the SOX2-OT Region - Unknown journal (n.d.) · Unknown authors · PubMed 26433762

  ABSTRACT: Background Bipolar disorder is a heterogeneous mood disorder associated with several important clinical comorbidities, such as eating disorders. This clinical heterogeneity complicates the identification of genetic variants contributing to bipolar susceptibility. Here we investigate comorbidity of eating disorders as a subphenotype of bipolar disorder to identify genetic variation that is common and unique to both disorders. Methods We performed a genome-wide association analysis contrasting 184 bipolar subjects with eating disorder comorbidity against both 1,370 controls and 2,006 subjects with bipolar disorder only from the Bipolar Genome Study (BiGS). Results The most significant genome-wide finding was observed bipolar with comorbid eating disorder vs. controls within SOX2-OT

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