Expressive

rs12148780 - ALDH1A2

Magnitude 2.0 · 2 studies on file

Reported associations

  • GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids - HGG advances (2025) · Sun Y, Xu H, Ye K · PubMed 40545721

    ABSTRACT: Summary Previous genome-wide association studies (GWAS) have identified genetic loci associated with the circulating levels of fatty acids (FAs), but the biological mechanisms of these genetic associations remain largely unexplored. Here, we conducted GWAS to identify additional genetic loci for 19 circulating FA traits in UK Biobank participants of European ancestry (n = 239,268) and five other ancestries (n = 508-4,663). We leveraged the GWAS findings to characterize genetic correlations and colocalized regions among FAs, explore sex differences, examine FA loci influenced by lipoprotein metabolism, and apply statistical fine-mapping to pinpoint putative causal variants. We integrated GWAS signals with multi-omics quantitative trait loci (QTL) to reveal intermediate molecular

  • Shared genetic architecture between metabolic traits and Alzheimer's disease: A large scale genome-wide cross-trait analysis - Human genetics (2019) · Zhu Z, Lin Y, Li X, Driver JA, Liang L · PubMed 30805717

    ABSTRACT: A growing number of studies clearly demonstrate a substantial link between metabolic dysfunction and the risk of Alzheimer's disease (AD), especially glucose related dysfunction; one hypothesis for this comorbidity is the presence of a common genetic etiology. We conducted a large-scale cross-trait GWAS to investigate the genetic overlap between AD and 10 metabolic traits. Among all the metabolic traits, fasting glucose, fasting insulin and HDL were found to be genetically associated with AD. Local genetic covariance analysis found 19q13 region had strong local genetic correlation between AD and T2D (P=6.78×10−22), LDL (P=1.74×10−253) and HDL (P=7.94×10−18). Cross-trait meta-analysis identified 4 loci that were associated with AD and fasting glucose, 3 loci that were a

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