rs12147450 - PNP - RNASE10

Magnitude 2.0 · 1 study on file

Reported associations

• Genome-wide association study of movement-related adverse antipsychotic effects - Biological psychiatry (2010) · Aberg K, Adkins DE, Bukszár J, Webb BT, Caroff SN, Miller DD, Sebat J, Stroup S, Fanous AH, Vladimirov VI, McClay JL, Lieberman JA, Sullivan PF, van den Oord EJ · PubMed 19875103

  ABSTRACT: Background Understanding individual differences in the development of extra-pyramidal side effects (EPS) as a response to antipsychotic therapy is essential to individualize treatment. Methods We performed genome-wide association studies to search for genetic susceptibility to EPS. Our sample consists of 738 schizophrenia patients, genotyped for 492K SNPs. We studied three quantitative measures of antipsychotic adverse drug reactions, the Simpson-Angus scale (SAS) for parkinsonism, the Barnes akathisia rating scale, and the abnormal involuntary movement scale (AIMS) as well as a clinical diagnosis of probable tardive dyskinesia. Results Two SNPs for SAS, rs17022444 and rs2126709 with p=1.2×10-10 and p=3.8×10-7, respectively, and one for AIMS, rs7669317 with p=7.7×10-8, reached

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