rs12145688 - SPATA21
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-Wide Interaction Study of Dietary Intake and Colorectal Cancer Risk in the UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 38411962
ABSTRACT: Key Points Question Which variants and genes modify the association of dietary intake with colorectal cancer (CRC) risk, and what are the underlying pathways for diet-CRC associations? Findings In this nested case-control study including 4686 patients with incident CRC and 14 058 matched controls, 324 variants suggestively interacted with 11 dietary factors, and multiple variants of EPDR1 were found to interact with fish intake on CRC risk. Several pathways were detected for the association between milk, cheese, tea, and alcohol consumption and CRC risk. Meaning The findings of this study support evidence for possible pathways involved in the association between diet and CRC. Importance Candidate gene analysis approaches have shown that colorectal cancer (CRC) risk attributable
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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limit milk and dairy intake Moderate
G allele interacts with milk intake to increase colorectal cancer risk
reduce daily milk and dairy consumption; consider lactose-free alternatives
Screening
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colorectal cancer screening consultation Moderate
Genetic variant associated with increased colorectal cancer risk
discuss appropriate screening timeline based on genetic risk